Call us 24/7: + 1(925)399 0085

Get your paper done by an expert

No matter what kind of academic paper you need, it is simple and secure to hire an essay writer for a price you can afford at StudyAcer. Save more time for yourself.

WhatsApp + 1(925)399 0085
$ 10
free
  • bibliography
  • title page
  • revisions
per page
19 k happy customers
4.7 out of 5 satisfaction rate
27 writers active

Statistic: 2 questions

 

1.      A new diagnostic test has been developed to Diagnose Disease Y. The new test was compared to the standard diagnostic test (“the gold standard”) on the same set of patients, and the following data were obtained:

 

 

 

Number of patients diagnosed by the new test as having Disease Y, who actually had Disease Y = 3,252

 

Number of patients in the group who were diagnosed by the standard test as having Disease Y = 4,579

 

Number of patients diagnosed by the new test as not having Disease Y = 4, 737

 

Number of patients diagnosed by the new test as having Disease Y, who actually do not have Disease Y= 784

 

 

 

The standard diagnostic test is a tissue biopsy, and therefore, is considered to be 100% sensitive for diagnosing Disease Y.

 

 

 

a.       Create the 2×2 table that shows this data

 

 

 

b.      Calculate:

 

 

 

                                                                          i.      The sensitivity of the new test

 

                                                                        ii.      The specificity of the new test

 

                                                                      iii.      The false positive rate of the new test

 

                                                                      iv.      The false negative rate of the new test

 

                                                                        v.      The positive predictive value of the new test

 

                                                                      vi.      The negative predictive value of the new test

 

                                                                    vii.      The likelihood ratio positive for the new test

 

                                                                  viii.      The likelihood ratio negative for the new test

 

 

 

 

 

 

 

 

 

2.      Two new tests have been developed to diagnose Condition Z. One test (Test A) measures a metabolite “Metabolite A” in the serum. The other test (Test B) measures a different metabolite, “Metabolite B” in the urine. After appropriate preliminary testing, human trials are conducted. Following informed consent, the two tests were run on a group of patients with each patient getting both tests, as well as the “gold standard” test for diagnosing Condition Z. The following data were obtained:

 

Important!!!! Since some answers depend on the results you obtained in previous sections of the problem, it is important for you that you show *all* work, since I will give partial credit if your analysis and set up are correct, even if your numerical result is incorrect.

 

 

 

 

 

Serum level (metabolite A)     # of patients                Disease positive                      Disease negative

 

(mg / ml)                                                                      (by gold standard)      (by gold standard)

 

 

 

0 – 1.99                                                 25                                22                                3

 

2.0 – 3.99                                273                              201                              72       

 

4.0 – 5.99                                584                              572                              12

 

6.0 – 7.99                                538                              529                                9

 

8.0 – 9.99                                175                              170                                5

 

>10.0                                         14                                14                                0

 

 

 

 

 

Urine level (metabolite B)

 

(ng/ml)

 

 

 

 

 

0 – 2.99                                                 30                                  5                              25

 

3.0 – 5.99                                245                                46                                         199      

 

6.0 – 8.99                                423                              400                              23

 

9.0 – 11.99                              628                              620                                8

 

12.0 – 14.99                            175                              169                                6

 

15.0 – 17.99                              99                                95                                4

 

>18.0                                           9                                  9                                0

 

 

 

a)      For test A, a cutoff value of 4.0 mg / ml of metabolite A is chosen as the boundary between a negative and a positive test result (i.e., values below 4.0 mg / ml  are considered “negative” and values of 4.0 mg / ml or greater are considered “positive”).

 

 

 

For test B, a cutoff value of 6.0 ng / ml for metabolite B is chosen as the boundary between a negative and a positive test result (i.e., values below 6.0 ng / ml are considered “negative” and values of 6.0 ng / ml or greater are considered “positive”).

 

 

 

                                                              i.      Create a fully labeled 2 x 2 table for test A

 

                                                            ii.      Create a fully labeled 2 x 2 table for test B

 

                                                          iii.      Which test is the more sensitive at diagnosing Condition Z?

 

                                                          iv.      Which test is the more specific at diagnosing Condition Z?

 

 

 

 

 

b)      What is the post-test probability of disease being present in a patient with a positive test result for test A if the pre-test probability of Condition Z is 8%, and the cutoff value of 4.0 mg/ml is chosen?

 

Our guarantees

Study Acers provides students with tutoring and help them save time, and excel in their courses. Students LOVE us!No matter what kind of essay paper you need, it is simple and secure to hire an essay writer for a price you can afford at StudyAcers. Save more time for yourself. Delivering a high-quality product at a reasonable price is not enough anymore.
That’s why we have developed 5 beneficial guarantees that will make your experience with our service enjoyable, easy, and safe.

Money-back guarantee

You have to be 100% sure of the quality of your product to give a money-back guarantee. This describes us perfectly. Make sure that this guarantee is totally transparent.

Read more

Zero-plagiarism guarantee

Each paper is composed from scratch, according to your instructions. It is then checked by our plagiarism-detection software. There is no gap where plagiarism could squeeze in.

Read more

Free-revision policy

Thanks to our free revisions, there is no way for you to be unsatisfied. We will work on your paper until you are completely happy with the result.

Read more

Privacy policy

Your email is safe, as we store it according to international data protection rules. Your bank details are secure, as we use only reliable payment systems.

Read more

Fair-cooperation guarantee

By sending us your money, you buy the service we provide. Check out our terms and conditions if you prefer business talks to be laid out in official language.

Read more

Our Homework Writing Disciplines

With a highly diverse team in almost all academic fields including:


Warning: Invalid argument supplied for foreach() in /home/acemfljg/public_html/wp-content/themes/essay-writing/footer.php on line 12